AS04

Adjuvant System 04 or AS04 is a trade name for combination of adjuvants used in various vaccine products by GlaxoSmithKline, in particular the Fendrix hepatitis B vaccine. It is also one of the ingredients of the human papillomavirus vaccine (HPV). Studies of AS04-adjuvanted HPV vaccine showed high and justified immune response against to HPV antigens.[1] Furthermore, patients who took HPV-16/18 AS04-adjuvanted vaccine previously showed strong rapid responses upon receiving subsequent doses.[2]

It consists of aluminum hydroxide and monophosphoryl lipid A (MPL). Furthermore, it is the successor of AS03 which is a squalene based adjuvant approved for pandemic vaccine by the EMA.[3]

References
  1. Morel, Sandra (2011). "BioDrugs". 25: 217–226. Cite journal requires |journal= (help)
  2. Mocicki, A (2012). Vaccine. 31. pp. 234–241.
  3. Plotkin; et al. Vaccines 6th ed. Elsevier Saunders. pp. 58–79. ISBN 978-1-4557-0090-5.

See also


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