Hydrocortisone aceponate

Hydrocortisone aceponate is a corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions).[1] It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid.

See also: hydrocortisone
Hydrocortisone aceponate
Clinical data
AHFS/Drugs.comMonograph
Routes of
administration		Topical
ATC code
Identifiers
IUPAC name
  • (11β)-21-(acetyloxy)-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.184.885
Chemical and physical data
FormulaC26H36O7
Molar mass460.567 g·mol−1
3D model (JSmol)
SMILES
  • CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)C
InChI
  • InChI=1S/C26H36O7/c1-5-22(31)33-26(21(30)14-32-15(2)27)11-9-19-18-7-6-16-12-17(28)8-10-24(16,3)23(18)20(29)13-25(19,26)4/h12,18-20,23,29H,5-11,13-14H2,1-4H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1 N
  • Key:MFBMYAOAMQLLPK-FZNHGJLXSA-N N
 NY (what is this?)  (verify)

References
  1. Mukhopadhyay AK, Baghel V (2010). "A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients". Indian Journal of Dermatology, Venereology and Leprology. 76 (5): 591. doi:10.4103/0378-6323.69093. PMID 20827017.
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