Hyoscyamine/hexamethylenetetramine/phenyl salicylate/methylene blue/benzoic acid

The drug combination hyoscyamine/­hexamethylenetetramine/­phenyl salicylate/­methylene blue/­benzoic acid (trade names Methylphen, Prosed DS) is used for the treatment of urinary tract infections.[1][2]

"Methylphen" redirects here. For the active ingredient of Ritalin, see Methylphenidate.
Hyoscyamine/­hexamethylenetetramine/­phenyl salicylate/­methylene blue/­benzoic acid
Combination of
HyoscyamineAntimuscarinic
HexamethylenetetramineBactericide/bacteriostatic
Phenyl salicylateNSAID
Methylene blueAntiseptic
Benzoic acidAcidifier
Clinical data
Trade namesMethylphen, Prosed DS
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		By mouth
Identifiers
ChemSpider
  • none

Mechanism of action

Hyoscyamine is an antimuscarinic agent which reduces spasms of the urinary bladder's smooth muscles. Hexamethylenetetramine (also called methenamine) is hydrolyzed to formaldehyde, which acts as a bactericidal or bacteriostatic agent. Phenyl salicylate is a mild pain reliever from the class of nonsteroidal anti-inflammatory drugs (NSAIDs). Methylene blue is a weak antiseptic. Benzoic acid lowers the pH in the urine, which is necessary for hexamethylenetetramine hydrolysis,[1][2] and generates an unfavourable environment for bacteria.

Prosed EC and Prosed ED delayed-release tablets additionally contain atropine, which is closely related to hyoscyamine and has the same kind of pharmacological action.[3][4]

References
  1. FDA Professional Drug Information on Methylphen.
  2. RxList: Prosed DS.
  3. Micromedex Detailed Consumer Information on Prosed EC.
  4. Consumer Drug Information on Prosed ED delayed-release tablets.


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