List of investigational antipsychotics

This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Receptor modulators

Monoamine receptor modulators
  • ATI-9242 – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)[1]
  • AVN-211 (CD-008-0173) – 5-HT6 receptor antagonist[2]
  • Brilaroxazine (RP-5063, RP-5000; oxaripiprazole) – atypical antipsychotic (D2 receptor partial agonist, 5-HT2A receptor antagonist, other actions)[3]
  • F-17464 – D3 receptor antagonist, 5-HT1A receptor partial agonist, and weak D2 receptor partial agonist[4]
  • FKF-02SC (TGOF-02N) – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)[5]
  • Lu-AF35700 – D1, 5-HT2A, and 5-HT6 receptor antagonist[6]
  • Masupirdine (SUVN-502) – 5-HT6 receptor antagonist[7]
  • SEP-363856 (SEP-856) – 5-HT1A receptor and TAAR1 agonist[8]
  • SUVN-D4010 – 5-HT4 receptor partial agonist[9]
  • TAK-058 (ENV-8058) – 5-HT3 receptor antagonist[10]

Glutamate receptor modulators

Acetylcholine receptor modulators

Cannabinoid receptor modulators

Other/mixed receptor modulators

Enzyme inhibitors
  • BI-409306 (SUB-166499) – phosphodiesterase 9A inhibitor[25]
  • Lu-AF11167 – dual phosphodiesterase 2A and 10A inhibitor[26]
  • OMS-824 (OMS-643762) – phosphodiesterase 10A inhibitor[27]
  • Sodium benzoate (SND-11, SND-12, SND-13, SND-14; Clozaben, NaBen) – D-amino acid oxidase inhibitor[28]
  • TAK-831 – D-amino acid oxidase inhibitor[29]

Ion channel modulators

Others
  • ADE-615 – undefined mechanism of action[32]
  • ADE-616 – undefined mechanism of action[33]
  • AMG-581 – undefined mechanism of action[34]
  • ASP-4345 – undefined mechanism of action[35]
  • ASP-6981 – undefined mechanism of action[36]
  • ATx11-004 – undefined mechanism of action[37]
  • MK-8189 – undefined mechanism of action[38]
  • PF-06266047 – undefined mechanism of action[39]
  • Pyridoxamine (BST-4001, K-163, K-163SZ; Pyridorin) – vitamin B6, advanced glycosylation end-product inhibitor, oxygen radical scavenger[40]
  • TS-134 (TS-1341) – undefined mechanism of action[41]

See also

References
  1. "ATI 9242 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  2. "AVN 211 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  3. "Brilaroxazine - Reviva Biopharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  4. "F 17464 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  5. "FKF 02SC - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  6. "Lu AF35700 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  7. "Masupirdine - Suven Life Sciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  8. "SEP 363856 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  9. "SUVN D4010 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  10. "TAK 058 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  11. "Neboglamine - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  12. "BIIB 104 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  13. "Pomaglumetad methionil - Denovo Biopharma/Eli Lilly and Company - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  14. "APN 1125 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  15. "APN 1125 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  16. "AX 1604 - Axim Biotech - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  17. "Cannabidiol - GW Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  18. "Cannabidiol - Echo Pharmaceuticals - AdisInsight". adisinsight.springer.com. Retrieved 14 February 2020.
  19. "Basmisanil - Roche - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  20. "Deudextromethorphan - Avanir Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  21. Nguyen, Linda; Thomas, Kelan L.; Lucke-Wold, Brandon P.; Cavendish, John Z.; Crowe, Molly S.; Matsumoto, Rae R. (2016-03). "Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders". Pharmacology & Therapeutics. 159: 1–22. doi:10.1016/j.pharmthera.2016.01.016. ISSN 1879-016X. PMID 26826604. Check date values in: |date= (help)
  22. "Erteberel - Eli Lilly and Company - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  23. "Olanzapine/samidorphan - Alkermes plc - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  24. "Roluperidone - Minerva Neurosciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  25. "BI 409306 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  26. "Lu AF11167 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  27. "OMS 824 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  28. "Sodium benzoate - SyneuRx - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  29. "TAK 831 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  30. "AUT 00206 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  31. "Evenamide - Newron Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  32. "ADE 615 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  33. "ADE 616 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  34. "AMG 581 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  35. "ASP 4345 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  36. "ASP 6981 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  37. "Atx11 004 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  38. "MK 8189 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  39. "PF 06266047 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  40. "Pyridoxamine - NephroGenex/Kowa - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  41. "TS 134 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.


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