Sabarubicin

Sabarubicin (MEN-10755), a disaccharide analog of doxorubicin, is used for the treatment of small cell lung cancer (SCLC).[1] It has been seen to show superior antitumour efficacy, which is purported to be linked to the activation of p53-independent apoptosis.[2]

Sabarubicin
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC32H37NO13
Molar mass643.642 g·mol−1
3D model (JSmol)
SMILES
  • C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@@H](O[C@H](C[C@@H]2O)O[C@H]3C[C@@](Cc4c3c(c5c(c4O)C(=O)c6ccccc6C5=O)O)(C(=O)CO)O)C)N)O
InChI
  • InChI=InChI=1S/C32H37NO13/c1-12-26(37)17(33)7-21(43-12)46-31-13(2)44-22(8-18(31)35)45-19-10-32(42,20(36)11-34)9-16-23(19)30(41)25-24(29(16)40)27(38)14-5-3-4-6-15(14)28(25)39/h3-6,12-13,17-19,21-22,26,31,34-35,37,40-42H,7-11,33H2,1-2H3/t12-,13-,17-,18-,19-,21-,22-,26+,31-,32-/m0/s1

References
  1. http://www.ema.europa.eu/docs/en_GB/document_library/Orphan_designation/2009/10/WC500005793.pdf
  2. Topics in Current Chemistry. 2008. 283. 171-189.


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