Taselisib

Taselisib (development code: GDC-0032) is an experimental cancer drug in development by Roche. It is a small molecule inhibitor targeting the p110α protein product of the phosphoinositide 3-kinase gene, PIK3CA.[1]

Taselisib
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • 2-{4-[2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H28N8O2
Molar mass460.542 g·mol−1
3D model (JSmol)
SMILES
  • CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C
InChI
  • InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
  • Key:BEUQXVWXFDOSAQ-UHFFFAOYSA-N

Taselisib is in phase III clinical trials for treatment of metastatic breast cancer ("Sandpiper") and non-small cell lung cancer ("Lung-MAP").[2]

References
  1. "Definition of taselisib - NCI Drug Dictionary - National Cancer Institute". Cancer.gov. Retrieved 2017-01-10.
  2. "Clinical Trials Search Results". clinicaltrials.gov. Retrieved 2019-08-30.


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