Amlodipine/valsartan
Amlodipine/valsartan is a blood pressure lowering combination drug. It contains amlodipine, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin receptor blocker.[2] This combination is usually well tolerated and effective for the reduction of blood pressure.[3]
 | |
 | |
| Combination of | |
|---|---|
| Amlodipine | Calcium channel blocker |
| Valsartan | Angiotensin II receptor antagonist |
| Clinical data | |
| Trade names | Exforge |
| AHFS/Drugs.com | Professional Drug Facts |
| License data |
|
| Pregnancy category |
|
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| KEGG | |
| CompTox Dashboard (EPA) | |
| (verify) | |
The combination was patented by Novartis Pharmaceuticals and sold under the brand name Exforge. The patent expired in September 2012.[4]
Amlodipine/valsartan is available in different dose preparations: 5 mg/160 mg, 10 mg/160 mg, 5 mg/320 mg and 10/320 mg of amlodipine and valsartan, respectively.[5]
The combination is also available with included hydrochlorothiazide, for patients who need a three-drug regimen to manage their blood pressure.[6]
References
- "Amlodipine / valsartan (Exforge) Use During Pregnancy". Drugs.com. 11 July 2019. Retrieved 13 February 2020.
- "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- Eckert S, Freytag SB, Müller A, Klebs SH (September 2013). "Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors". Blood Pressure. 22 (sup1): 11–21. doi:10.3109/08037051.2013.793891. PMID 23713686. S2CID 25814898.
- "Generic Exforge HCT". Blood-pressure.emedtv.com. Retrieved 2012-03-05.
- "Exforge- amlodipine besylate and valsartan tablet, film coated". DailyMed. 12 June 2019. Retrieved 12 February 2020.
- "Exforge HCT- amlodipine valsartan and hydrochlorothiazide tablet, film coated". DailyMed. Retrieved 12 February 2020.
External links
- "Amlodipine mixture with valsartan". Drug Information Portal. U.S. National Library of Medicine.
- "Amlodipine besylate mixture with hydrochlorothiazide and valsartan". Drug Information Portal. U.S. National Library of Medicine.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.