Cismadinone acetate

Cismadinone acetate, also known as 6α-chloro-δ1-dehydro-17α-acetoxyprogesterone or as 6α-chloro-17α-acetoxypregna-1,4-diene-3,20-dione, is a steroidal progestin related to the 17α-hydroxyprogesterone derivatives which was never marketed.[1] It is the acetylated form of cismadinone, which is also a progestin but, similarly to cismadinone acetate, was never marketed.[2]

Not to be confused with Chlormadinone acetate.
Cismadinone acetate
Clinical data
Other names6α-chloro-δ1-dehydro-17α-acetoxyprogesterone; 6α-Chloro-1,2-didehydro-17α-acetoxyprogesterone; 6α-Chloro-17α-acetoxypregna-1,4-diene-3,20-dione
Drug classProgestogen; Progestogen ester
Identifiers
IUPAC name
  • (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-8-chloro-2,15-dimethyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-14-yl acetate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H29ClO4
Molar mass404.93 g·mol−1
3D model (JSmol)
SMILES
  • CC(=O)C1(CCC2C1(CCC3C2CC(C4=CC(=O)C=CC34C)Cl)C)OC(=O)C
InChI
  • InChI=1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h5,8,11,16-18,20H,6-7,9-10,12H2,1-4H3/t16-,17+,18+,20+,21-,22+,23+/m1/s1
  • Key:AQDNTKZTMCWYDA-WXLIAARGSA-N

See also

References
  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 284. ISBN 978-1-4757-2085-3.
  2. World Health Organization (2013), The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances (PDF), p. 104



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