Vericiguat

Vericiguat, sold under the brand name Verquvo, is a medication used to reduce the risk of cardiovascular death and heart failure.[1][2] It is taken by mouth.[1][2]

Vericiguat
Clinical data
Trade namesVerquvo
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classSoluble guanylate cyclase activator
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.247.370
Chemical and physical data
FormulaC19H16F2N8O2
Molar mass426.388 g·mol−1
3D model (JSmol)
SMILES
  • COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N
InChI
  • InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)
  • Key:QZFHIXARHDBPBY-UHFFFAOYSA-N

Common side effects include low blood pressure and low red cell count (anemia).[2]

Vericiguat is a soluble guanylate cyclase (sGC) stimulator.[1] It was approved for medical use in the United States in January 2021.[2][3]

Medical uses

Vericiguat is indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.[1][2]

Adverse effects

Vericiguat causes harm to the unborn baby and should not be given to pregnant women.[2]

History

The U.S. Food and Drug Administration (FDA) approved vericiguat based on evidence from a clinical trial (NCT02861534) which consisted of 5,050 participants aged 23 to 98 years old with worsening heart failure.[2] The trial was conducted at 694 sites in 42 countries in Europe, Asia, North and South America.[2] The trial enrolled participants with symptoms of worsening heart failure.[2] Participants were randomly assigned to receive vericiguat or a placebo pill once a day.[2] Neither the participants nor the health care professionals knew if the participants were given vericiguat or placebo pill until after the trial was complete.[2]

References
  1. "Verquvo- vericiguat tablet, film coated". DailyMed. Retrieved 9 February 2021.
  2. "Drug Trials Snapshot: Verquvo". U.S. Food and Drug Administration (FDA). 8 February 2021. Retrieved 8 February 2021. This article incorporates text from this source, which is in the public domain.
  3. "Verquvo: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 19 January 2021.

Further reading
  • Armstrong PW, Pieske B, Anstrom KJ, Ezekowitz J, Hernandez AF, Butler J, et al. (May 2020). "Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction". N Engl J Med. 382 (20): 1883–1893. doi:10.1056/NEJMoa1915928. PMID 32222134.
  • "Vericiguat". Drug Information Portal. U.S. National Library of Medicine.
  • Clinical trial number NCT02861534 for "A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001) (VICTORIA)" at ClinicalTrials.gov


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